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Manna, P. K.
- Hepatoprotectant Activity of Alcoholic Extract of Andrographis paniculata Entrapped in Calcium Alginate Micropellets
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PDF Views:492
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Journal of Natural Remedies, Vol 7, No 2 (2007), Pagination: 283-288Abstract
Andrographis paniculata, an established hepatoprotectant is widely used in many polyherbal formulations. The main problem with the drug is its bitterness, which causes gastric discomfort, loss of appetite, nausea and vomiting on regurgitation and in turn leads to patient non-compliance. The aim of the present study was to mask the bitterness of Andrographis paniculata to encourage its use as a monoherbal hepatoprotectant preparation. The extract of Andrographis paniculata (30%w/w of andrographolide) was entrapped into micropellets of calcium alginate for bitter taste masking and the so formed pellets were evaluated for hepatoprotectant activity in paracetamol induced hepatotoxicity in rats. The micropellets containing alcoholic extract of Andrographis paniculata equivalent to 22.5mg/kg body weight of the alcoholic extract of Andrographis paniculata were given orally to animals for a period of 9 days. The activity observed was compared with alcoholic extract of Andrographis paniculata. The bitterless alginate micropellets loaded with alcoholic extract of Andrographis paniculata were found to successfully inhibit the paracetamol induced hepatotoxiciy as indicated by a decrease in AST, ALT, ALP and liver weight. The effect observed was supported by histopathological studies. It was concluded that micropellets prepared by inotropic gelation of calcium alignate can be used to mask the bitterness of Andrographis paniculata without affecting its activity.Keywords
Andrographis paniculata, Bitter Taste Masking, Ionotropic Gelation, Micropellets, Hepatoprotective, Paracetamol- Antibacterial and Antifungal Activity of Andrographis echiodes
Abstract Views :464 |
PDF Views:678
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Journal of Natural Remedies, Vol 3, No 2 (2003), Pagination: 185-188Abstract
Objective: To investigate the antibacterial and antifungal activity of chloroform, acetone, methanol and aqueous extracts of whole plant Andrographis echiodes. Materials and methods: Antimicrobial activity was studied at different concentrations of the extract dissolved in dimethyl sulfoxide against seven strains of bacteria, three strains of fungi and one yeast by disc diffusion method. The minimum inhibitory concentration of the extracts were also determined. Results: All the extracts except aqueous posses antimicrobial activity against most of the organisms tested. The minimum inhibitory concentrations ranges from 0.05 mg/ml to 5 mg/ml on tested bacteria. Conclusion: The activities of Andrographis echiodes confirms with its folk use as remedy for fever. In addition to this use it may also be used topically for treatment of bacterial and fungal infections.Keywords
Andrographis echiodes, Antibacterial and Antifungal Activity, Bacteria. Fungi, Yeast- Studies on Hepatoprotective Effect of Flaveria trinervia
Abstract Views :441 |
PDF Views:473
Authors
S. Umadevi
,
G. P. Mohanta
,
R. Kalaiselvan
,
P. K. Manna
,
R. Manavalan
,
S. Sethupathi
,
K. Shantha